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Inspite of all recent therapeutic developments, a proportion of individuals will nevertheless fail to respond and should be considered for curative therapy. Presently, only allogeneic hematopoietic mobile transplantation is usually thought of likely curative, but it is also associated with sizeable morbidity and mortality.
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This methylation profile is previously acquired for the MBL stage3 and remains rather stable eventually. Nonetheless, some CLL have intratumor variability in certain areas, which can alter the expression of various genes and facilitate tumor evolution.seventy one Of note, this variability is larger in U-CLL than in M-CLL and is particularly connected with expanding variety of subclones.seven,71
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